Nuclear PDCD4 Expression Defines a Subset of Luminal B-Like Breast Cancers with Good Prognosis
نویسندگان
چکیده
منابع مشابه
Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis.
Breast cancer is a heterogeneous disease made of various molecular subtypes with different prognosis. However, evolution remains difficult to predict within some subtypes, such as luminal A, and treatment is not as adapted as it should be. Refinement of prognostic classification and identification of new therapeutic targets are needed. Using oligonucleotide microarrays, we profiled 227 breast c...
متن کاملYoung age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression.
PURPOSE Breast cancer arising in young women is correlated with inferior survival and higher incidence of negative clinicopathologic features. The biology driving this aggressive disease has yet to be defined. PATIENTS AND METHODS Clinically annotated, microarray data from 784 early-stage breast cancers were identified, and prospectively defined, age-specific cohorts (young: </= 45 years, n =...
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Aim To study the prognostic value of immunohistochemically detected low Claudin3 expression in breast cancers. Methods This retrospective study included patients with breast cancer who were investigated at our unit from 2006 to 2015. Tissue microarrays were constructed, and immunohistochemical staining was done to assess the Claudin3 expression and to classify breast cancers according to the ...
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BACKGROUND p63 is a member of the p53 family that has been implicated in maintenance of epithelial stem cell compartments. Previous studies demonstrated that p63 is downregulated in muscle-invasive bladder cancers, but the relationship between p63 expression and survival is not clear. METHODOLOGY/PRINCIPAL FINDINGS We used real-time PCR to characterize p63 expression and several genes implica...
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BACKGROUND Oestrogen receptor (ER) positive (luminal) tumours account for the largest proportion of females with breast cancer. Theirs is a heterogeneous disease presenting clinical challenges in managing their treatment. Three main biological luminal groups have been identified but clinically these can be distilled into two prognostic groups in which Luminal A are accorded good prognosis and L...
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ژورنال
عنوان ژورنال: Hormones and Cancer
سال: 2020
ISSN: 1868-8497,1868-8500
DOI: 10.1007/s12672-020-00392-4